Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fubp1tm1.1Dlev
Name:	far upstream element (FUSE) binding protein 1; targeted mutation 1.1, David Levens
MGI ID:	MGI:5789037
Synonyms:	Fubp1-
Gene:	Fubp1  Location: Chr3:151916059-151942463 bp, + strand  Genetic Position: Chr3, 77.05 cM
Alliance:	Fubp1tm1.1Dlev page

Germline Transmission:	Earliest citation of germline transmission: J:229985
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted between exons 7 and 8 and a loxP and frt-flanked neomycin selection cassette was inserted between exons 13 and 14. After FLP and Cre-mediated recombination, a deletion of exons 8-13 was created, with a single loxP and a single frt site remaining at the deletion site. This deletion removes K homology (KH) motifs 2, 3 and the amino terminal half of KH4, yielding an allele that is incapable of expressing a protein that binds properly with single-strand nucleic acids. Immunoblot analysis confirmed the absence of protein expression in primary MEFs derived from E13.5 homozygous mutant embryos. (J:229985)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fubp1 Mutation:	54 strains or lines available

Original:	J:229985 Zhou W, et al., Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. Am J Pathol. 2016 Mar;186(3):701-15
All:	1 reference(s)