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Cybatm1Dgh
Targeted Allele Detail
Nomenclature
Symbol: Cybatm1Dgh
Name: cytochrome b-245, alpha polypeptide; targeted mutation 1, David G Harrison
MGI ID: MGI:5775909
Synonyms: p22phox/flox
Gene: Cyba  Location: Chr8:122424776-122432930 bp, - strand  Genetic Position: Chr8, 71.04 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:231269
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin resistance cassette was inserted 7.1 kb upstream of the transcription start site. An additional loxP site was inserted in intron 1. (J:231269)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyba Mutation:  8 strains or lines available
References
Original:  J:231269 Lob HE, et al., Role of the NADPH oxidases in the subfornical organ in angiotensin II-induced hypertension. Hypertension. 2013 Feb;61(2):382-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory