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Esr2tm1.1Gust
Targeted Allele Detail
Summary
Symbol: Esr2tm1.1Gust
Name: estrogen receptor 2 (beta); targeted mutation 1.1, Jan-Ake Gustafsson
MGI ID: MGI:5751115
Synonyms: ERbeta-, ERbeta-deltaex3
Gene: Esr2  Location: Chr12:76167193-76224033 bp, - strand  Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
Alliance: Esr2tm1.1Gust page
Esr2tm1.1Gust/Esr2tm1.1Gust mouse ovaries display more atretic follicles and less corpora lutea than wild-type mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220968
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and a floxed neo cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 3. (J:220968)
Generation of the Esr2tm1Gust and Esr2tm1.1Gust alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr2 Mutation:  32 strains or lines available
References
Original:  J:220968 Maneix L, et al., Estrogen receptor beta exon 3-deleted mouse: The importance of non-ERE pathways in ERbeta signaling. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5135-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory