Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pde6htm1.1Bewi
Name:	phosphodiesterase 6H, cGMP-specific, cone, gamma; targeted mutation 1.1, Bernd Wissinger
MGI ID:	MGI:5702758
Synonyms:	L1
Gene:	Pde6h  Location: Chr6:136929216-136940483 bp, + strand  Genetic Position: Chr6, 66.72 cM
Alliance:	Pde6htm1.1Bewi page

Germline Transmission:	Earliest citation of germline transmission: J:222177
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed the loxP flanked exons 2-4 and the Neo/TK selection cassette. Immunofluorescence analysis confirmed absence of protein in the retina. (J:222177)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde6h Mutation:	11 strains or lines available

Original:	J:222177 Brennenstuhl C, et al., Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory. J Biol Chem. 2015 Apr 17;290(16):10242-55
All:	1 reference(s)