Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(tetO-PTPN11*E76K)#Jiwu
Name:	transgene insertion, Jie Wu
MGI ID:	MGI:5688299
Synonyms:	tetO-SHP2E76K
Transgene:	Tg(tetO-PTPN11*E76K)#Jiwu  Location: unknown
Alliance:	Tg(tetO-PTPN11*E76K)#Jiwu page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Constitutively active, Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-PTPN11*E76K)#Jiwu expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human PTPN11 (5781) Ptpn11  (MGI:99511)   Mutation details: The chicken beta-globin insulator sequence and tetracycline operator are used to drive inducible expression of a constitutively active human PTPN11 containing the E76K mutation with a C-terminal Flag tag. A pair of oppositely oriented heterotypic L3 and L2 loxP sites flank the transgenic cassette. Three lines that show no leaky expression of the transgene were created: 398, 425, and 417. However, the pound symbol (#) is used when the line is not specified and/or lines are pooled. (J:212505)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:212505 Schneeberger VE, et al., SHP2E76K mutant promotes lung tumorigenesis in transgenic mice. Carcinogenesis. 2014 Aug;35(8):1717-25
All:	2 reference(s)