Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol: Cep290Gt(CC0582)Wtsi Name: centrosomal protein 290; gene trap CC0582, Wellcome Trust Sanger Institute MGI ID: MGI:3870362 Synonyms: Cep290gt, Cep290LacZ Gene: Cep290  Location: Chr10:100323410-100409527 bp, + strand  Genetic Position: Chr10, 51.48 cM Alliance: Cep290Gt(CC0582)Wtsi page

Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi mice exhibit progressive renal collecting duct cystic disease Show the 3 phenotype image(s) involving this allele.

Mutant Cell Line:	CC0582
Germline Transmission:	Earliest citation of germline transmission: J:212182
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Allele Type:    Gene trapped (Hypomorph) Mutation:    Insertion of gene trap vector     Vector: pGT0lxfT2   Mutation details: The gene was disrupted by a gene trap insertion within intron 23 and resulted in a hypomorphic mutation. The gene trap contains a beta-galactosidase/neomycin reporter gene with a ribosomal reentry site (IRES) followed by a poly(A) tail. Genomic DNA PCR confirmed the insertion of the gene trap and localized it to 3.308 kb downstream of exon 24. (J:212182) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select CC0582 DU635568 (MGI Seq Detail) 5' RACE Chr10:100359089-100359264 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 3 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

Generation of the Cep290Gt(CC0582)Wtsi allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cep290 Mutation:	126 strains or lines available

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	7 reference(s)