Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(SFTPC-KIF5B/RET)1Tkoh
Name:	transgene insertion 1, Takashi Kohno
MGI ID:	MGI:5661918
Synonyms:	KIF5B-RET
Transgene:	Tg(SFTPC-KIF5B/RET)1Tkoh  Location: unknown
Alliance:	Tg(SFTPC-KIF5B/RET)1Tkoh page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(SFTPC-KIF5B/RET)1Tkoh expresses 2 genes Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human KIF5B (3799) Kif5b  (MGI:1098268) human RET (5979) Ret  (MGI:97902)   Mutation details: The human KIF5B-RET fusion cDNA bearing a FLAG-tag at the N-terminus is under the control of a type 2 alveolar epithelium-specific surfactant protein C promoter. RT-PCR and Western blot analysis confirmed expression of the fusion mRNA and protein in the lungs. This line carries approximately six copies of the transgene. (J:215989)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:215989 Saito M, et al., A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis. Carcinogenesis. 2014 Nov;35(11):2452-6
All:	1 reference(s)