Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw
Targeted Allele Detail
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| Symbol: |
Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw |
| Name: |
collagen, type I, alpha 1; targeted mutation 5, Kwok-Kin Wong |
| MGI ID: |
MGI:5661327 |
| Synonyms: |
FGFR2W290C |
| Gene: |
Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
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| Alliance: |
Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw page
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| Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw expresses
1 gene
Knock-in expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
FGFR2 (2263) |
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Mutation details: The chicken beta-actin (CAG) promoter, a loxP flanked STOP cassette, and human FGFR2 cDNA with the extracellular W290C domain activating mutation were inserted into the mouse collagen A1 locus . Upon cre-mediated recombination, the STOP cassette is excised promoting expression of the mutant FGFR2.
(J:214230)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Col1a1 Mutation: |
160 strains or lines available
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| Original: |
J:214230 Tchaicha JH, et al., Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Res. 2014 Sep 1;74(17):4676-84 |
| All: |
1 reference(s) |
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Analysis Tools
