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Fostm1.1Fawa
Targeted Allele Detail
Nomenclature
Symbol: Fostm1.1Fawa
Name: FBJ osteosarcoma oncogene; targeted muation 1.1, Fan Wang
MGI ID: MGI:5660357
Synonyms: FosTVA
Gene: Fos  Location: Chr12:85473901-85477269 bp, + strand  Genetic Position: Chr12, 39.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:242828
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe targeting vector contains a 2A sequence, followed by a destabilized nuclear CFP (nuclear localized CFP fused with "PEST" sequence), 2A sequence, followed by destabilized TVA (TVA fused with "PEST" sequence), bGH polyA. An FRT-flanked PGK-NEO cassette was inserted adjacent to the STOP codon in exon 4, of the Fos gene. "PEST" sequence targets the protein for degradation by fusing amino acids 422-462 from the degradation domain of mouse ornithine decarboxylase to the C-terminal of the reporter/protein (in this case CFP and TVA). (J:242828)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fos Mutation:  28 strains or lines available
References
Original:  J:242828 Sakurai K, et al., Capturing and Manipulating Activated Neuronal Ensembles with CANE Delineates a Hypothalamic Social-Fear Circuit. Neuron. 2016 Nov 23;92(4):739-753
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory