Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm4(Sry)Aqui
Name:	collagen, type I, alpha 1; targeted mutation 4, Alexander Quinn
MGI ID:	MGI:5638904
Synonyms:	Sry#49
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm4(Sry)Aqui page

Germline Transmission:	Earliest citation of germline transmission: J:215196
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Col1a1tm4(Sry)Aqui expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Sry (MGI:98660)   Mutation details: RMCE on KH2 ES cells introduced into the 3' UTR the Sry coding region with 1313 bp of the upstream flanking inverted repeat and downstream inverted repeat up to but not including the StuI restriction site followed by an ampillicin resistance gene, PGK promoter, hygromycin resistance gene and polyadenylation sequence. FRT sites flank the entire insertion. (J:215196)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:215196 Quinn A, et al., A site-specific, single-copy transgenesis strategy to identify 5' regulatory sequences of the mouse testis-determining gene Sry. PLoS One. 2014;9(4):e94813
All:	1 reference(s)