Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Neurog2tm1.1Meg
Name:	neurogenin 2; targeted mutation 1.1, Michael E Greenberg
MGI ID:	MGI:5638453
Synonyms:	Ngn2S231A&S234A
Gene:	Neurog2  Location: Chr3:127426784-127429280 bp, + strand  Genetic Position: Chr3, 56.54 cM, cytoband H1
Alliance:	Neurog2tm1.1Meg page

Germline Transmission:	Earliest citation of germline transmission: J:221029
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Nucleotide substitution resulted in the amino acid substitution of serine with alanine at positions 231 and 234 (p.S231A, p.S234A), abolishing phosphorylation potential at those residues. Serine codon 218 was changed from TCA to AGC as a silent mutation to create a diagnostic SacI restriction site. Cre-mediated recombination removed a loxP site flanked neomycin resistance gene cassette that was inserted downstream of the gene. (J:221029)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurog2 Mutation:	18 strains or lines available

Original:	J:221029 Ma YC, et al., Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron. 2008 Apr 10;58(1):65-77
All:	1 reference(s)