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Fosbtm2.1Yun
Targeted Allele Detail
Summary
Symbol: Fosbtm2.1Yun
Name: FBJ osteosarcoma oncogene B; targeted mutation 2.1, Yusaku Nakabeppu
MGI ID: MGI:5634957
Synonyms: fosBG
Gene: Fosb  Location: Chr7:19036621-19043970 bp, - strand  Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
Alliance: Fosbtm2.1Yun page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220448
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA destabilized variant of the enhanced green fluorescent protein (EGFP) was inserted in frame in exon 2 and the remainder of exon 2 and all of exon 3 were replaced by a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:220449)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fosb Mutation:  22 strains or lines available
References
Original:  J:220449 Ohnishi YN, et al., Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell. 2008 Nov;19(11):4717-29
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory