Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Pou4f2tm1.2(cre)Tcba
Name:	POU domain, class 4, transcription factor 2; targeted mutation 1.2, Tudor Constantin Badea
MGI ID:	MGI:5629706
Synonyms:	Brn3bCre
Gene:	Pou4f2  Location: Chr8:79159639-79163274 bp, - strand  Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
Alliance:	Pou4f2tm1.2(cre)Tcba page

Germline Transmission:	Earliest citation of germline transmission: J:215125
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Pou4f2tm1.2(cre)Tcba expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pou4f2 (MGI:102524)   Mutation details: The targeting construct introduced into the 3'UTR three polyadenylation squences, a RoxP site, a cre recombinase gene and an FRT-flanked neomycin resistance cassette. An additional RoxP site was inserted upstream of the translation start site. Flp-mediated recombination removed the selection cassette. Dre-mediated recombination removed the coding sequence and 3 polyadenylation sequence. (J:215125)

Activity:	Tissue activity of this recombinase allele
Driver:	Pou4f2 (mouse) Summary of all recombinase alleles driven by Pou4f2. Comparative matrix view of recombinase activities Alliance mouse Pou4f2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou4f2 Mutation:	7 strains or lines available

Original:	J:215125 Sajgo S, et al., Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice. PLoS One. 2014;9(3):e91435
All:	2 reference(s)