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Stk11tm2Tpm
Targeted Allele Detail
Summary
Symbol: Stk11tm2Tpm
Name: serine/threonine kinase 11; targeted mutation 2, Tomi P Makela
MGI ID: MGI:2387004
Gene: Stk11  Location: Chr10:79951637-79966516 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Stk11tm2Tpm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70892
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsSequence encoding exons 2 through 7 were flanked by single loxP sites inserted into introns 1 and 7 in inverse orientations. A neo cassette was also inserted immediately downstream of the intron 7 loxP site. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Stk11tm2.1Tpm. (J:70892)
Tumor Data
List all tumor models in MMHCdb carrying Stk11tm2Tpm
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  34 strains or lines available
References
Original:  J:70892 Ylikorkala A, et al., Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory