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Mtf1tm1c(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Mtf1tm1c(KOMP)Wtsi
Name: metal response element binding transcription factor 1; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5621187
Synonyms: Mtf1fl
Gene: Mtf1  Location: Chr4:124802549-124849800 bp, + strand  Genetic Position: Chr4, 57.91 cM, cytoband D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212038
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 124819771 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 124820731. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:212038)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtf1 Mutation:  11 strains or lines available
References
Original:  J:212038 Kim JH, et al., Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell. 2014 Feb 13;156(4):730-43
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory