Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkx2-5tm1.1Wtp
Name:	NK2 homeobox 5; targeted mutation 1.1, William T Pu
MGI ID:	MGI:5606034
Synonyms:	CVDC/B2B program mutation, Nkx2-5flbio
Gene:	Nkx2-5  Location: Chr17:27057638-27063962 bp, - strand  Genetic Position: Chr17, 13.6 cM
Alliance:	Nkx2-5tm1.1Wtp page

Germline Transmission:	Earliest citation of germline transmission: J:185868
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae
Project Collection:	B2B/CvDC

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a FLAG/bio epitope tag and a frt-flanked neomycin resistance (neo) cassette at the endogenous Nkx2-5 stop codon and upstream of the 3' UTR. FLP mediated recombination removed the FRT-flanked neo cassette. (J:185868)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:	21 strains or lines available

Original:	J:185868 Schramm C, Information about alleles developed by members of the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program. MGI Direct Data Submission. 2012;
All:	1 reference(s)