Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mesp2tm5(Notch1)Ysa
Name:	mesoderm posterior 2; targeted mutation 5, Yumiko Saga
MGI ID:	MGI:2386850
Synonyms:	Mesp2N
Gene:	Mesp2  Location: Chr7:79460475-79463179 bp, + strand  Genetic Position: Chr7, 45.18 cM
Alliance:	Mesp2tm5(Notch1)Ysa page

Germline Transmission:	Earliest citation of germline transmission: J:78989
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Constitutively active, Inserted expressed sequence, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mesp2tm5(Notch1)Ysa expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Notch1 (MGI:97363)   Mutation details: The coding sequences were replaced by an in-frame Notch1 intracellular cDNA sequence followed by a PGK-neomycin resistance cassette. This allele expresses an activated form of NOTCH1 under the control of the Mesp2 promoter. (J:78989)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mesp2 Mutation:	30 strains or lines available

Original:	J:78989 Takahashi Y, et al., Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat Genet. 2000 Aug;25(4):390-6
All:	2 reference(s)