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Gopctm1.1Tno
Targeted Allele Detail
Summary
Symbol: Gopctm1.1Tno
Name: golgi associated PDZ and coiled-coil motif containing; targeted mutation 1.1, Tetsuo Noda
MGI ID: MGI:2386794
Synonyms: GOPC-
Gene: Gopc  Location: Chr10:52213120-52258220 bp, - strand  Genetic Position: Chr10, 26.54 cM, cytoband B3
Alliance: Gopctm1.1Tno page
Ultrastructural analysis of spermatogenic cells from wild type and Gopctm1.1Tno/Gopctm1.1Tno mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78599
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was excised from Gopctm1Tno by the in vivo expression of cre recombinase. A lacZ gene remained in place of exons 2, 2b, and 3. Neither of the two protein isoforms produced by the endogenous locus were detected in homozygous mutant mice by Western blot and immunohistochemical analyses. (J:78599)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gopc Mutation:  25 strains or lines available
References
Original:  J:78599 Yao R, et al., Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11211-6
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory