Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Blnktm1Kplm
Name:	B cell linker; targeted mutation 1, Kong-Peng Lam
MGI ID:	MGI:2386672
Synonyms:	BLNK-, SLP-65-
Gene:	Blnk  Location: Chr19:40917371-40982664 bp, - strand  Genetic Position: Chr19, 34.26 cM
Alliance:	Blnktm1Kplm page

Germline Transmission:	Earliest citation of germline transmission: J:61130
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first coding exon and 4.5 kb of upstream sequence were replaced by a neomycin selection cassette. Expression was undetected in homozygous mutant mice by RT-PCR analysis of bone marrow and spleen samples. (J:61130)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Blnk Mutation:	76 strains or lines available

Original:	J:61130 Xu S, et al., B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int Immunol. 2000 Mar;12(3):397-404
All:	5 reference(s)