Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm7(tetO-Jund/Fos)Wag
Name:	collagen, type I, alpha 1; targeted mutation 7, Erwin F Wagner
MGI ID:	MGI:5586536
Synonyms:	Col1a1TetOP-JunD~c-Fos
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm7(tetO-Jund/Fos)Wag page

Germline Transmission:	Earliest citation of germline transmission: J:210545
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm7(tetO-Jund/Fos)Wag expresses 2 genes Knock-in expresses: Organism Expressed Gene Note mouse Fos (MGI:95574) mouse Jund (MGI:96648)   Mutation details: KH2 ES cells were retargeted with a "flp-in plasmid" containing a tetracycline responsive element (TRE or tetO) and a forced dimerization fusion cDNA of Jund lacking the stop codon and Fos connected by a flexible short polyGly-Ser peptide with a C-terminal FLAG-tag. A flpe-recombinase plasmid facilitated integration into the 3' UTR region. (J:210545)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:210545 Hasenfuss SC, et al., Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metab. 2014 Jan 7;19(1):84-95
All:	1 reference(s)