Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm2(tetO-Fosl2,-DsRed)Wag
Name:	collagen, type I, alpha 1; targeted mutation 2, Erwin F Wagner
MGI ID:	MGI:5585642
Synonyms:	tet-O-Fosl2
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm2(tetO-Fosl2,-DsRed)Wag page

Germline Transmission:	Earliest citation of germline transmission: J:211215
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready, Reporter) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm2(tetO-Fosl2,-DsRed)Wag expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Fosl2 (MGI:102858)   Mutation details: KH2 ES cells were retargeted with a "flp-in plasmid containing a tetracycline responsive element (TRE or tetO), FLAG-tagged Fosl2 cDNA sequence, GtX IRES sequence and DsRed reporter. A flpe-recombinase plasmid facilitated integration into the 3' UTR region. (J:211215)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

16 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:211215 Bozec A, et al., Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism. J Cell Sci. 2013 Dec 1;126(Pt 23):5432-40
All:	6 reference(s)