Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Xbp1tm1.1Geno
Name:	X-box binding protein 1; targeted mutation 1.1, Genoway
MGI ID:	MGI:5576515
Synonyms:	XBP1loxP
Gene:	Xbp1  Location: Chr11:5470659-5475893 bp, + strand  Genetic Position: Chr11, 3.61 cM
Alliance:	Xbp1tm1.1Geno page

Germline Transmission:	Earliest citation of germline transmission: J:211440
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted into the promoter. An FRT-flanked neomycin resistance cassette with a loxP site was inserted into intron 2. Flp-mediated recombination removed the selection cassette and left exon 1 floxed. (J:211440)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xbp1 Mutation:	28 strains or lines available

Original:	J:211440 Zeng L, et al., Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation. 2013 Apr 23;127(16):1712-22
All:	7 reference(s)