Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kmotm1.2Pjmi
Name:	kynurenine 3-monooxygenase; targeted mutation 1.2, Paul J Muchowski
MGI ID:	MGI:5569396
Gene:	Kmo  Location: Chr1:175459759-175488419 bp, + strand  Genetic Position: Chr1, 81.6 cM
Alliance:	Kmotm1.2Pjmi page

Germline Transmission:	Earliest citation of germline transmission: J:207199
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exon 5 floxed. Cre-mediated recombination removed exon 5. Western blot analysis confirmed the absence of protein expression in the brain and liver. (J:207199)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmo Mutation:	36 strains or lines available

Original:	J:207199 Giorgini F, et al., Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. J Biol Chem. 2013 Dec 20;288(51):36554-66
All:	4 reference(s)