Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Zic2em4Bend Name: zinc finger protein of the cerebellum 2; endonuclease-mediated mutation 4, Ben Davies MGI ID: MGI:5566855 Synonyms: C3H-10, Zic2A10 Gene: Zic2  Location: Chr14:122712847-122717264 bp, + strand  Genetic Position: Chr14, 65.97 cM Alliance: Zic2em4Bend page

Curly tail in a Zic2em4Bend/Zic2+ founder Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

C3H/HeH

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: TALEN mediated recombination introduced a 2 bp deletion resulting in a Lysine to Asparagine mutation at amino acid 399 and a frameshift mutation (p.Lys399Asnfs*17). (J:199882)

TALEN mediated recombination scheme used to generate the Zic2em1Bend, Zic2em2Bend, Zic2em3Bend, Zic2em4Bend and Zic2em5Bend alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zic2 Mutation:	41 strains or lines available

Original:	J:199882 Davies B, et al., Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes. PLoS One. 2013;8(3):e60216
All:	2 reference(s)