b2b2463Clo Chemically induced Allele Detail MGI Mouse (MGI:5560904)

b2b2463Clo
Chemically induced Allele Detail

Summary

Symbol:	b2b2463Clo
Name:	Mutant line 2463; Bench to Bassinet Program (B2B/CVDC), mutation 2463 Cecilia Lo
MGI ID:	MGI:5560904
Gene:	b2b2463Clo Location: unknown
Alliance:	b2b2463Clo page

Mutant 2463-003-1 (E17.5) shows parallel outflow tracts, indicating possible DORV, which was confirmed by EFIC imaging

Show the 8 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:	C57BL/6J
Project Collection:	B2B/CvDC

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b2463Clo, and may be present in stocks carrying this mutation.

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any b2b2463Clo Mutation:	1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular Phenotype: Overriding aorta/double outlet right ventricle (DORV), muscular ventricular septal defect
Noncardiovascular Phenotype: Hypoplastic thymus, growth retarded.

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
1300	Ventricular septal defect
1432	Overriding aortic valve
4906	Non-cardiac abnormality

References

Original:	J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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