Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rapgef3tm1.1Chen
Name:	Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1.1, Ju Chen
MGI ID:	MGI:5559594
Synonyms:	Epac1-
Gene:	Rapgef3  Location: Chr15:97642651-97665853 bp, - strand  Genetic Position: Chr15, 53.74 cM
Alliance:	Rapgef3tm1.1Chen page

Germline Transmission:	Earliest citation of germline transmission: J:207599
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 3. A neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 2 through 5. Western blot analysis confirmed the absence of protein expression in the heart, liver, pancreas and kidney. (J:207599)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rapgef3 Mutation:	45 strains or lines available

Original:	J:207599 Yan J, et al., Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol. 2013 Mar;33(5):918-26
All:	11 reference(s)