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Chrna1tm1b(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Chrna1tm1b(EUCOMM)Hmgu
Name: cholinergic receptor nicotinic alpha 1 subunit; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5548913
Synonyms: Chrna1lacZ
Gene: Chrna1  Location: Chr2:73393625-73410682 bp, - strand  Genetic Position: Chr2, 43.76 cM
Alliance: Chrna1tm1b(EUCOMM)Hmgu page
IMPC: Chrna1 gene page
Mutation
origin
Mutant Cell Line:  HEPD0507_1_B05
Germline Transmission:  Earliest citation of germline transmission: J:204739
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsCre-mediated excision of the parental Chrna1tm1a(EUCOMM)Hmgu allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrna1 Mutation:  17 strains or lines available
References
Original:  J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory