Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-Ab1b-tm1Wug
Name:	histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Gregory F Wu
MGI ID:	MGI:5543894
Synonyms:	H2-Ab1tm1Wug, IAbetabstopf
Gene:	H2-Ab1  Location: Chr17:34482201-34488392 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-Ab1b-tm1Wug page

Germline Transmission:	Earliest citation of germline transmission: J:204951
Parent Cell Line:	LK-1/LK1 (ES Cell)
Strain of Origin:	C57BL/6NHsd

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutation:    Insertion   Mutation details: A floxed neomycin resistance/STOP cassette was inserted into intron 1. Flow cytometry confirmed the absence of protein expression in the peripheral blood, spleen and bone marrow. (J:204951)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:	78 strains or lines available

Original:	J:204951 Archambault AS, et al., Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol. 2013 Jul 15;191(2):545-50
All:	4 reference(s)