Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Samhd1tm2.2Crs
Name:	SAM domain and HD domain, 1; targeted mutation 2.2, Caetano Reis e Sousa
MGI ID:	MGI:5543257
Synonyms:	Samhd1 ko
Gene:	Samhd1  Location: Chr2:156939454-156977016 bp, - strand  Genetic Position: Chr2, 78.0 cM, cytoband H2
Alliance:	Samhd1tm2.2Crs page

Germline Transmission:	Earliest citation of germline transmission: J:201909
Parent Cell Line:	S6B6 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6J)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2. Flp-mediated recombination removed the neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in bone marrow-derived dendritic cells and mouse embryonic fibroblasts. (J:201909)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Samhd1 Mutation:	36 strains or lines available

Original:	J:201909 Rehwinkel J, et al., SAMHD1-dependent retroviral control and escape in mice. EMBO J. 2013 Sep 11;32(18):2454-62
All:	1 reference(s)