Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Stra6tm2.1Nbg
Name:	stimulated by retinoic acid gene 6; targeted mutation 2.1, Norbert B Ghyselinck
MGI ID:	MGI:5532504
Synonyms:	Stra6L2
Gene:	Stra6  Location: Chr9:57971071-58061279 bp, + strand  Genetic Position: Chr9, 31.63 cM, cytoband C
Alliance:	Stra6tm2.1Nbg page

Germline Transmission:	Earliest citation of germline transmission: J:203449
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette and left exons 5 through 7 floxed. This allele was used to generated Stra6tm1. (J:203449)

Generation of the Stra6tm2.1Nbg and Stra6tm1Nbg alleles

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stra6 Mutation:	48 strains or lines available

Original:	J:203449 Berry DC, et al., The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem. 2013 Aug 23;288(34):24528-39
All:	1 reference(s)