Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Klf1tm1.1Ryan
Name:	Kruppel-like transcription factor 1 (erythroid); targeted mutation 1.1, Thomas Ryan
MGI ID:	MGI:5529812
Synonyms:	EGFP-EKLF
Gene:	Klf1  Location: Chr8:85628611-85631920 bp, + strand  Genetic Position: Chr8, 41.3 cM
Alliance:	Klf1tm1.1Ryan page

Mouse Generated:	Earliest citation of chimera generation: J:204029
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: An EGFP gene, with a three glycine codon (GGA GGT GGA) linker to created a fusion, was inserted into exon 1 between nucleotides 3424 and 3425 (GenBank Accession NO. AF019074.1). A floxed hygromycin and kanamycin resistance cassette was inserted downstream of exon 1. Cre-mediated recombination removed the selection cassette. (J:204029)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf1 Mutation:	21 strains or lines available

Original:	J:204029 Liu S, et al., Erythropoiesis in the absence of adult hemoglobin. Mol Cell Biol. 2013 Jun;33(11):2241-51
All:	1 reference(s)