Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chst14tm1.1Msch
Name:	carbohydrate sulfotransferase 14; targeted mutation 1.1, Melitta Schachner
MGI ID:	MGI:5528395
Gene:	Chst14  Location: Chr2:118756978-118759066 bp, + strand  Genetic Position: Chr2, 59.73 cM, cytoband E5
Alliance:	Chst14tm1.1Msch page

Germline Transmission:	Earliest citation of germline transmission: J:203583
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of the coding exon. An FRT- and loxP-flanked neomycin resistance cassette with a dsRED gene was inserted downstream of the coding exon. Cre-mediated recombination removed the coding exon and neomycin resistance cassette. RT-PCR and northern blot analysis confirmed the absence of transcript expression. (J:203583)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chst14 Mutation:	21 strains or lines available

Original:	J:203583 Akyuz N, et al., Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration. Exp Neurol. 2013 Sep;247:517-30
All:	2 reference(s)