Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Darren Moore
MGI ID:	MGI:5527542
Synonyms:	R26-LRRK2
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human LRRK2 (120892) Lrrk2  (MGI:1913975)   Mutation details: The targeting vector contains a SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a full-length human leucine-rich repeat kinase 2 cDNA bearing a familial Parkinson's disease-linked missense mutation R1441C, and a bovine polyadenylation signal. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	2 reference(s)