Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Aire-cre/ERT2*)1Mand
Name:	transgene insertion 1, Mark Anderson
MGI ID:	MGI:5527371
Synonyms:	Aire-Cre
Transgene:	Tg(Aire-cre/ERT2*)1Mand  Location: unknown
Alliance:	Tg(Aire-cre/ERT2*)1Mand page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Aire-cre/ERT2*)1Mand expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Aire   Mutation details: A targeting construct was used for recombineering to insert an ERT2-cre-ERT2 sequence (cre fused to two mutated human estrogen receptor ligand-binding domains) into a BAC containing the Aire locus. The inducible cre cassette replaced exon 2 of Aire. The resulting linearized BAC was injected into fertilized FVB oocytes. Founder and line number information is not available. (J:203553)

Activity:	Tissue activity of this recombinase allele
Driver:	Aire (species not specified) Summary of all recombinase alleles driven by Aire. Comparative matrix view of recombinase activities

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:203553 Metzger TC, et al., Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013 Oct 17;5(1):166-79
All:	4 reference(s)