Col1a1tm1(tetO-EML4/ALK)Kkw
Targeted Allele Detail
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| Symbol: |
Col1a1tm1(tetO-EML4/ALK)Kkw |
| Name: |
collagen, type I, alpha 1; targeted mutation 1, Kwok-Kin Wong |
| MGI ID: |
MGI:5527336 |
| Synonyms: |
EML4-ALK |
| Gene: |
Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
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| Alliance: |
Col1a1tm1(tetO-EML4/ALK)Kkw page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:166724
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Humanized sequence, Inducible, Inserted expressed sequence) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Col1a1tm1(tetO-EML4/ALK)Kkw expresses
2 genes
Knock-in expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
ALK (238) |
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| human |
EML4 (27436) |
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Col1a1tm1(tetO-EML4/ALK)Kkw expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
tetO |
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Mutation details: The human EML4 and ALK variant 1 fusion under the control of the doxycycline inducible Tet-op promoter was knocked into the locus.
(J:166724)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Col1a1 Mutation: |
160 strains or lines available
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| Original: |
J:166724 Chen Z, et al., Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene. Cancer Res. 2010 Dec 1;70(23):9827-9836 |
| All: |
4 reference(s) |
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Analysis Tools
