Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Eef1a1tm1(FBXW7*)Iaai
Name:	eukaryotic translation elongation factor 1 alpha 1; targeted mutation 1, Iannis Aifantis
MGI ID:	MGI:5524154
Synonyms:	Eef1a1mutW7
Gene:	Eef1a1  Location: Chr9:78385735-78389006 bp, - strand  Genetic Position: Chr9, 43.65 cM, cytoband E1
Alliance:	Eef1a1tm1(FBXW7*)Iaai page

Germline Transmission:	Earliest citation of germline transmission: J:200006
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neomycin resistance cassette and an N-terminally flag tagged human cDNA encoding a mutant form with the R465C substitution were inserted into intron 1. Cre-mediated recombination is required to achieve expression of the cDNA. (J:200006)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eef1a1 Mutation:	60 strains or lines available

Original:	J:200006 King B, et al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 2013 Jun 20;153(7):1552-66
All:	2 reference(s)