Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Lats2tm1.1Hlee
Name:	large tumor suppressor 2; targeted mutation 1.1, Ho Lee
MGI ID:	MGI:5518609
Synonyms:	Lats2fl, Lats2flox
Gene:	Lats2  Location: Chr14:57927119-57983669 bp, - strand  Genetic Position: Chr14, 30.28 cM
Alliance:	Lats2tm1.1Hlee page

Germline Transmission:	Earliest citation of germline transmission: J:198940
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 3. A second loxP site was inserted into intron 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:198940)

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lats2 Mutation:	42 strains or lines available

Original:	J:198940 Kim M, et al., cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J. 2013 May 29;32(11):1543-55
All:	6 reference(s)