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Targeted Allele Detail
Symbol: Sox2tm1.1(cre/ERT2)Jpmb
Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Juan Pedro Martinez Barbera
MGI ID: MGI:5512893
Synonyms: Sox2CreERT2, Sox2tm1.1(cre)Jpmb
Gene: Sox2  Location: Chr3:34650405-34652461 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Germline Transmission:  Earliest citation of germline transmission: J:201265
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Mutation detailsHomologous recombination in ES cells inserted a cre/ERT2-PGK-neo cassette into the Sox2 locus, generating a knockin allele that functionally is a null allele of Sox2. The frt-flanked neo marker was deleted by crossing animals with Tg(ACTFLPe)9205Dym mice. Lineage tracing in embryos from tamoxifen treated females of R26YFP and Sox2Cre/ERT2 intercrosses demonstrated labelled cells at P1 in tissues that normally express Sox2 (brain, eyes, ears, oral epithelia). (J:201265)
 Tissue activity of this recombinase allele
Driver: Sox2     Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:  23 strains or lines available
Original:  J:201265 Andoniadou CL, et al., Sox2 Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential. Cell Stem Cell. 2013 Oct 3;13(4):433-445
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory