Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox2tm1.1(cre/ERT2)Jpmb
Name:	SRY (sex determining region Y)-box 2; targeted mutation 1.1, Juan Pedro Martinez Barbera
MGI ID:	MGI:5512893
Synonyms:	Sox2CreERT2, Sox2tm1.1(cre)Jpmb
Gene:	Sox2  Location: Chr3:34704554-34706610 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance:	Sox2tm1.1(cre/ERT2)Jpmb page

Germline Transmission:	Earliest citation of germline transmission: J:201265
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Sox2tm1.1(cre/ERT2)Jpmb expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sox2 (MGI:98364)   Mutation details: Homologous recombination in ES cells inserted a cre/ERT2-PGK-neo cassette into the Sox2 locus, generating a knockin allele that functionally is a null allele of Sox2. The frt-flanked neo marker was deleted by crossing animals with Tg(ACTFLPe)9205Dym mice. Lineage tracing in embryos from tamoxifen treated females of R26YFP and Sox2Cre/ERT2 intercrosses demonstrated labelled cells at P1 in tissues that normally express Sox2 (brain, eyes, ears, oral epithelia). (J:201265)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:	56 strains or lines available

Original:	J:201265 Andoniadou CL, et al., Sox2 Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential. Cell Stem Cell. 2013 Oct 3;13(4):433-445
All:	13 reference(s)