Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Myh6tm2e(EUCOMM)Hmgu
Name:	myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:5511310
Gene:	Myh6  Location: Chr14:55179378-55204384 bp, - strand  Genetic Position: Chr14, 28.01 cM
IMPC:	Myh6 gene page

Mutant Cell Lines:	HEPD0813_3_B05, HEPD0813_3_B08, HEPD0813_3_F08
Germline Transmission:	Unknown
Parent Cell Line:	JM8A3.N1.C2 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	EUCOMM

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 55201853 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Myh6 Mutation:	206 strains or lines available

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	1 reference(s)