Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Scn1atm1Kea
Name:	sodium channel, voltage-gated, type I, alpha; targeted mutation 1, Jennifer Kearney
MGI ID:	MGI:5510417
Gene:	Scn1a  Location: Chr2:66101125-66271181 bp, - strand  Genetic Position: Chr2, 39.13 cM
Alliance:	Scn1atm1Kea page

Germline Transmission:	Earliest citation of germline transmission: J:203040
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP-flanked neomycin resistance cassette replaced the first coding exon. Absence of protein was confirmed by immunoblotting. (J:203040)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn1a Mutation:	114 strains or lines available

Original:	J:203040 Miller AR, et al., Mapping genetic modifiers of survival in a mouse model of Dravet syndrome. Genes Brain Behav. 2014 Feb;13(2):163-72
All:	40 reference(s)