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Ptentm1Engc
Targeted Allele Detail
Summary
Symbol: Ptentm1Engc
Name: phosphatase and tensin homolog; targeted mutation 1, Charis Eng
MGI ID: MGI:5509194
Synonyms: Pten-m3m4, PtenM3M4
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance: Ptentm1Engc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200739
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  CD-1
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsFive missense mutations were introduced into the nuclear localization sequences 3 and 4 in exon 7 and a neo selection cassette was inserted in intron 7 via homologous recombination. The expressed protein is localized predominantly in the cytoplasm. (J:200739, J:210487)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  81 strains or lines available
References
Original:  J:200739 Mester JL, et al., Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. Eur J Hum Genet. 2011 Jul;19(7):763-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory