Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igktm1.1(b12)Nemz
Name:	immunoglobulin kappa chain complex; targeted mutation 1.1, David Nemazee
MGI ID:	MGI:5505300
Synonyms:	b10L
Gene:	Igk  Location: Chr6:67532620-70703738 bp, + strand  Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Germline Transmission:	Earliest citation of germline transmission: J:205766
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin resistance cassette replace the J cluster in the Igk locus with the HIV antibody b12 L chain VJ element. Cre-mediated recombination removed the neomycin resistance cassette. (J:205766)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igk Mutation:	25 strains or lines available

Original:	J:205766 Ota T, et al., B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates. J Immunol. 2013 Sep 15;191(6):3179-85
All:	2 reference(s)