Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 11, Ralf Kuhn
MGI ID:	MGI:5503124
Synonyms:	BRAFV637EERT2
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn page

Germline Transmission:	Earliest citation of germline transmission: J:196873
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(C57BL/6J x 129S6/SvEvTac)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    tamoxifen Mutation:    Insertion   Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Braf (MGI:88190)   Mutation details: Recombinase mediated cassette exchange involving Gt(ROSA)26Sortm1Rkuhn introduced into the locus a CAG promoter, floxed stop cassette and a fusion of the mouse cDNA containing the amino acid substitution of glutamic acid for valine at position 673 and an N-terminus nuclear export signal to the modified estrogen receptor (ERT2). The mutation is equivalent to the human mutation V600E. (J:196873)

Generation of the Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:196873 Ortiz O, et al., Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in braf ER mice. Genesis. 2013 Feb 26;:1-8
All:	1 reference(s)