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Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Targeted Allele Detail
Nomenclature
Symbol: Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Name: pancreas specific transcription factor, 1a; targeted mutation 2, Ken-ichi Yamamura
MGI ID: MGI:5502956
Synonyms: Gm13336-Ptf1aPtf1a
Gene: Ptf1a  Location: Chr2:19445663-19447501 bp, + strand  Genetic Position: Chr2, 13.37 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195133
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsRecombination of Ptf1a/Ptf1aostm1Kymm exchanged the floxed neomycin resistance cassette with the Ptf1a open reading frame, FRT site, puromycin resistance cassette and lox2272 site. This allele was generated in ES cells containing Etn2Sd. (J:195133)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptf1a Mutation:  18 strains or lines available
References
Original:  J:195133 Semba K, et al., Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet. 2013 Feb;9(2):e1003204
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/05/2021
MGI 6.16
The Jackson Laboratory