Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptf1a/Ptf1aostm1Kymm
Name:	pancreas specific transcription factor 1a, opposite strand; targeted mutation 1, Ken-ichi Yamamura
MGI ID:	MGI:5502926
Synonyms:	Gm13336-Ptf1aneo
Gene:	Ptf1aos  Location: Chr2:19446319-19451485 bp, - strand  Genetic Position: Chr2, 13.36 cM
Alliance:	Ptf1a/Ptf1aostm1Kymm page

Germline Transmission:	Earliest citation of germline transmission: J:195133
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A loxP site, FRT site, neomycin resistance cassette, lox2272 site, polyadenylation sequence and FRT site replaced exon 1 of Ptf1a and exons 1 and 2 of Ptf1aos. RT-PCR confirmed the abscence of transcript expression of both transcripts in E9.5 embryos. This allele was generated in ES cells containing Etn2Sd. (J:195133)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptf1aos Mutation:	1 strain or line available

Original:	J:195133 Semba K, et al., Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet. 2013 Feb;9(2):e1003204
All:	1 reference(s)