Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1Jus
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Monica Justice
MGI ID:	MGI:5502574
Synonyms:	Gt(ROSA)26Sortm1(LSL-Prdm14-IRES-EGFP)Jus, Gt(ROSA)26Sortm1(Prdm14)Jus, R26PR
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1Jus page

Germline Transmission:	Earliest citation of germline transmission: J:202090
Parent Cell Line:	JM8A3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1Jus expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Prdm14 (MGI:3588194)   Mutation details: A loxP-PGK/Neo/pA-3XpA(STOP)-loxP-Prdm14-IRES-EGFP targeted to the locus. This allele provides a model for cre-inducible overexpression of Prdm14 and the EGFP marker. (J:202090)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:202090 Carofino BL, et al., A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013 Nov-Dec;6(6):1494-506
All:	3 reference(s)