Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nos3tm2.1Plh
Name:	nitric oxide synthase 3, endothelial cell; targeted mutation 2.1, Paul L Huang
MGI ID:	MGI:5499171
Synonyms:	eNosS1176A, eNosSA
Gene:	Nos3  Location: Chr5:24569808-24589472 bp, + strand  Genetic Position: Chr5, 11.32 cM
Alliance:	Nos3tm2.1Plh page

Germline Transmission:	Earliest citation of germline transmission: J:198075
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 26 was replaced with a modified one in which nucleotide substitions result in the amino acid substitution of alanine for serine at position 1176 (S1176A). Cre-mediated recombination removed a floxed neomycin resistance cassette. The predicted protein contains an unphosphorylatable (SA) mutation. (J:198075)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nos3 Mutation:	56 strains or lines available

Original:	J:198075 Kashiwagi S, et al., eNOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity. Biochem Biophys Res Commun. 2013 Feb 8;431(2):284-90
All:	6 reference(s)