Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Dock6tm2a(EUCOMM)Hmgu
Name:	dedicator of cytokinesis 6; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:5497354
Gene:	Dock6  Location: Chr9:21711476-21764006 bp, - strand  Genetic Position: Chr9, 7.89 cM, cytoband A4
IMPC:	Dock6 gene page

Mutant Cell Lines:	HEPD0868_3_A10, HEPD0868_3_A11, HEPD0868_3_B06, HEPD0868_3_C05, HEPD0868_3_C09, HEPD0868_3_C11, HEPD0868_3_D03, HEPD0868_3_D10, HEPD0868_3_D11, HEPD0868_3_E11, HEPD0868_3_F01, HEPD0868_3_F07, HEPD0868_3_F10, HEPD0868_3_G02, HEPD0868_3_G03, HEPD0868_3_G10, HEPD0868_3_H01, HEPD0868_3_H02, HEPD0868_3_H08, HEPD0868_3_H10
Germline Transmission:	Unknown
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 21754083 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 21756065. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Dock6 Mutation:	151 strains or lines available

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	1 reference(s)