Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(Slc12a5-LUC)Ldtk
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Wolfgang Liedtke
MGI ID:	MGI:5496010
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Slc12a5-LUC)Ldtk page

Germline Transmission:	Earliest citation of germline transmission: J:198265
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Reporter) Mutation:    Insertion   Mutation details: A 2.5 kb promoter region for the fore-brain specific isoform of Slc12a5 was inserted upstream of a codon optimized, red shifted, Italian firefly (Luciola italica) luciferase (redLUC). Luciferase expression in late embryonic cortical neurons paralleled known Slc12a5 expression. (J:198265)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:198265 Liedtke W, et al., Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2. Small. 2013 Apr 8;9(7):1066-75
All:	2 reference(s)