Dlg4tm1.1Tdoi
Targeted Allele Detail
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| Symbol: |
Dlg4tm1.1Tdoi |
| Name: |
discs large MAGUK scaffold protein 4; targeted mutation 1.1, Tomoko Doi |
| MGI ID: |
MGI:5495768 |
| Synonyms: |
1d2d-PSD-95-EGFP |
| Gene: |
Dlg4 Location: Chr11:69908029-69938107 bp, + strand Genetic Position: Chr11, 42.96 cM, cytoband B4
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| Alliance: |
Dlg4tm1.1Tdoi page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:197875
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| Parent Cell Line: |
Bruce 4 (ES Cell)
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| Strain of Origin: |
B6.Cg-Thy1a
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exons 5 through 8 were replaced with a modified full-length cDNA and EGFP fusion followed by a floxed neomycin resistance cassette. The modified cDNA contains the mutations S78N (AGC to AAC), A80V (GCA to GTA), S183N (AGC to AAC), and A185V (GCA to GTA), and the deletions T83 to I88 and V178 to I183 that mutate PDZ1/2 to resemble PDZ3. Cre-mediated recombination removed the neomycin resistance cassette.
(J:197875)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Dlg4 Mutation: |
42 strains or lines available
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| Original: |
J:197875 Nagura H, et al., Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. Mol Brain. 2012;5:43 |
| All: |
1 reference(s) |
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Analysis Tools
